Targeted Drug Delivery Within the Eye Through the Suprachoroidal Space

Targeted administration into the suprachoroidal space using a microneedle for drug delivery to the posterior segment of the eye.

PURPOSE This study seeks to determine the intraocular pharmacokinetics of molecules and particles injected into the suprachoroidal space of the rabbit eye in vivo using a hollow microneedle. METHODS Suprachoroidal injections of fluorescein and fluorescently tagged dextrans (40 and 250 kDa), bevacizumab, and polymeric particles (20 nm to 10 μm in diameter) were performed using microneedles in ...

Physiology and Pharmacology Targeted Administration into the Suprachoroidal Space Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye

METHODS. Suprachoroidal injections of fluorescein and fluorescently tagged dextrans (40 and 250 kDa), bevacizumab, and polymeric particles (20 nm to 10 lm in diameter) were performed using microneedles in New Zealand white rabbits. The fluorescence intensity within the eye was monitored in each animal using an ocular fluorophotometer to determine the distribution of the injected material in the...

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery

Suprachoroidal Drug Delivery: Unique New Observations.

Gu et al. use ultra-high resolution ocular coherence tomography (UHR-OCT) in the guinea pig eye model to evaluate suprachoroidal drug delivery using 10to 20-lL injections of either saline, indocyanine green (ICG), or triamcinolone acetate (TA). The authors have an elegantly designed study that measures the cross-sectional area of the suprachoroidal space (SCS) using these various injections at ...